Oral Mucosal Drug Delivery and Therapy

Oral Mucosal Drug Delivery and Therapy

Author: Michael J. Rathbone

Publisher: Springer

ISBN: 9781489975584

Category: Medical

Page: 279

View: 507

This volume provides a comprehensive overview of the current issues facing scientists working on delivering drugs locally and systemically via the membranes that line the mouth. The book describes the anatomical and physiological challenges of this route for drug delivery and how they impact the design of oral mucosal drug delivery systems. It also provides a detailed description of current oral mucosal drug delivery technologies that overcome these challenges alongside research, development and assessment methods. In 11 authoritative chapters, the book affords an in-depth evaluation of the major issues associated with this route of administration, namely the retention of the drug/product at the site of administration and increasing drug permeability through the oral mucosa. The book provides insights into the in vitro and in vivo methods available to assess drug permeability and retention, offers solutions on how to improve the permeation of the drugs through the oral mucosa, and explores approaches to prolong drug/product retention at the site of administration. It also indicates future directions in research and product development. Oral Mucosal Drug Delivery and Therapy is a key resource for those wishing to extend their knowledge of this field.

Development of Oral Mucosal Mucosal Drug Delivery for Motion Sickness

Development of Oral Mucosal Mucosal Drug Delivery for Motion Sickness

Author: Hitesh Patel

Publisher: LAP Lambert Academic Publishing

ISBN: 3844308806

Category:

Page: 64

View: 847

The work is planned for the removal of problem during motion Sickness especially in case of immediate and long term treatment is required.The work was focus for the development of single dosage form application for both fast and slow release action.The formulation can also be kept in to consideration of further clinical trials for their final approach. The commercial viability of the dosage form can be made very easy by conventional approach of manufacturing.The Scopolamine Hydrobromide was used a drug for the therapeutic effect. The film were prepared with different polymer to develop the best suitable approach for the development of novel drug delivery systems.The formulation can also be kept in future development by modifying several parameters.The project was planned for the patient convenience in terms dosage form intake and its dosing reduction with desire drug effect.

Fundamentals and Applications of Controlled Release Drug Delivery

Fundamentals and Applications of Controlled Release Drug Delivery

Author: Juergen Siepmann

Publisher: Springer Science & Business Media

ISBN: 9781461408802

Category: Medical

Page: 592

View: 368

Pitched at a level comprehensible to those new to the field, this authoritative text covers the scientific and technological fundamentals of drug delivery as well as clinical applications and the developmental potential in controlled release drug delivery.

Oral Controlled Release Formulation Design and Drug Delivery

Oral Controlled Release Formulation Design and Drug Delivery

Author: Hong Wen

Publisher: John Wiley & Sons

ISBN: 1118060326

Category: Science

Page: 376

View: 555

This book describes the theories, applications, and challenges for different oral controlled release formulations. This book differs from most in its focus on oral controlled release formulation design and process development. It also covers the related areas like preformulation, biopharmaceutics, in vitro-in vivo correlations (IVIVC), quality by design (QbD), and regulatory issues.

Fundamentals of Drug Delivery

Fundamentals of Drug Delivery

Author: Michael S. Roberts

Publisher: John Wiley & Sons

ISBN: 9781119769675

Category: Medical

Page: 580

View: 554

A comprehensive guide to the current research, major challenges, and future prospects of controlled drug delivery systems Controlled drug delivery has the potential to significantly improve therapeutic outcomes, increase clinical benefits, and enhance the safety of drugs in a wide range of diseases and health conditions. Fundamentals of Drug Delivery provides comprehensive and up-to-date coverage of the essential principles and processes of modern controlled drug delivery systems. Featuring contributions by respected researchers, clinicians, and pharmaceutical industry professionals, this edited volume reviews the latest research in the field and addresses the many issues central to the development of effective, controlled drug delivery. Divided in three parts, the book begins by introducing the concept of drug delivery and discussing both challenges and opportunities within the rapidly evolving field. The second section presents an in-depth critique of the common administration routes for controlled drug delivery, including delivery through skin, the lungs, and via ocular, nasal, and otic routes. The concluding section summarizes the current state of the field and examines specific issues in drug delivery and advanced delivery technologies, such as the use of nanotechnology in dermal drug delivery and advanced drug delivery systems for biologics. This authoritative resource: Covers each main stage of the drug development process, including selecting pharmaceutical candidates and evaluating their physicochemical characteristics Describes the role and application of mathematical modelling and the influence of drug transporters in pharmacokinetics and drug disposition Details the physiology and barriers to drug delivery for each administration route Presents a historical perspective and a look into the possible future of advanced drug delivery systems Explores nanotechnology and cell-mediated drug delivery, including applications for targeted delivery and toxicological and safety issues Includes comprehensive references and links to the primary literature Edited by a team of of internationally-recognized experts, Fundamentals of Drug Delivery is essential reading for researchers, industrial scientists, and advanced students in all areas of drug delivery including pharmaceutics, pharmaceutical sciences, biomedical engineering, polymer and materials science, and chemical and biochemical engineering.

Biopolymer-Based Composites

Biopolymer-Based Composites

Author: Sougata Jana

Publisher: Woodhead Publishing

ISBN: 9780081019153

Category: Technology & Engineering

Page: 422

View: 645

Biopolymer-Based Composites: Drug Delivery and Biomedical Applications presents a comprehensive review on recent developments in biopolymer-based composites and their use in drug delivery and biomedical applications. The information contained in this book is critical for the more efficient use of composites, as detailed up-to-date information is a pre-requirement. The information provided brings cutting-edge developments to the attention of young investigators to encourage further advances in the field of bio-composite research. Currently, biopolymers are being investigated for the design of various drug delivery and biomedical devices due to their non-toxic, biodegradable and biocompatible nature. Mostly, biopolymer-based solid orals, gels, hydrogel beads, and transdermal matrices have been designed in order to control drug/protein release in simulated bio-fluids. Presents the most updated information in the field of pharmaceutical and biological sciences Contains color figures and illustrations to help users understand key topics Useful guide for young researchers working towards new innovations Includes chapters covered by eminent scientists in the field

Nanomaterials

Nanomaterials

Author: Simona Clichici

Publisher: BoD – Books on Demand

ISBN: 9781789846164

Category: Technology & Engineering

Page: 246

View: 697

In the last decade, nanomaterials have become a double-edged sword. On one hand, nanomaterials have proven their limitless potential not only for technological applications, but also for medical ones. On the other hand, the increasing use of these nanomaterials has raised concerns regarding their safety for environmental and human health, due to their potential toxicity. The toxic effects of nanomaterials depend on their type, surface geometry, diameter, length and function. This book intends to provide a comprehensive evidence-based overview of nanomaterial toxicity, from their synthesis and characterization, environmental impact, tests to assess their toxicity in vitro and in vivo, ways to modulate their impact on living organisms, to their beneficial use in biomedical applications.

Diseases of the Oral Mucosa

Diseases of the Oral Mucosa

Author: Enno Schmidt

Publisher: Springer Nature

ISBN: 9783030828042

Category: Dentistry

Page: 537

View: 315

This textbook details the latest diagnostic and management options available when treating patients with diseases affecting the oral mucosa. It comprehensively covers the content required to successfully pass dermatology and stomatology board examinations, while being a valuable resource for dentistry trainees. Chapters cover aspects of mucosal immunity and clinical scores along with a range of diseases. Didactic features including learning objectives enable the reader to better extrapolate the key concepts covered in each chapter. Diseases of the Oral Mucosa: Study Guide and Review presents an in depth overview of the latest diagnostic tools and management options available for diseases of the oral mucosa and is an ideal resource for trainee and practising dentists, dermatologists and stomatologists preparing to sit board examinations.

Marine-Derived Biomaterials for Tissue Engineering Applications

Marine-Derived Biomaterials for Tissue Engineering Applications

Author: Andy H. Choi

Publisher: Springer

ISBN: 9789811388552

Category: Technology & Engineering

Page: 550

View: 814

This book presents the latest advances in marine structures and related biomaterials for applications in both soft- and hard-tissue engineering, as well as controlled drug delivery. It explores marine structures consisting of materials with a wide variety of characteristics that warrant their use as biomaterials. It also underlines the importance of exploiting natural marine resources for the sustainable development of novel biomaterials and discusses the resulting environmental and economic benefits. The book is divided into three major sections: the first covers the clinical application of marine biomaterials for drug delivery in tissue engineering, while the other two examine the clinical significance of marine structures in soft- and hard-tissue engineering, respectively. Focusing on clinically oriented applications, it is a valuable resource for dentists, oral and maxillofacial surgeons, orthopedic surgeons, and students and researchers in the field of tissue engineering.

Basic Fundamentals of Drug Delivery

Basic Fundamentals of Drug Delivery

Author:

Publisher: Academic Press

ISBN: 9780128179109

Category: Business & Economics

Page: 810

View: 582

Basic Fundamentals of Drug Delivery covers the fundamental principles, advanced methodologies and technologies employed by pharmaceutical scientists, researchers and pharmaceutical industries to transform a drug candidate or new chemical entity into a final administrable drug delivery system. The book also covers various approaches involved in optimizing the therapeutic performance of a biomolecule while designing its appropriate advanced formulation. Provides up-to-date information on translating the physicochemical properties of drugs into drug delivery systems Explores how drugs are administered via various routes, such as orally, parenterally, transdermally or through inhalation Contains extensive references and further reading for course and self-study

ADME Processes in Pharmaceutical Sciences

ADME Processes in Pharmaceutical Sciences

Author: Alan Talevi

Publisher: Springer

ISBN: 9783319995939

Category: Medical

Page: 362

View: 323

Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. As an introduction oriented to pharmacy students, it is also written for scientist from different fields outside of pharmaceutics. (e.g. material scientist, material engineers, medicinal chemists) who might be working in a positions in pharmaceutical companies or whose work might benefit from basic training in the ADME concepts and some biological background. Pedagogical features such as objectives, keywords, discussion questions, summaries and case studies add valuable teaching tools. This book will provide not only general knowledge on ADME processes but also an updated insight on some hot topics such as drug transporters, multi-drug resistance related to pharmacokinetic phenomena, last generation pharmaceutical carriers (nanopharmaceuticals), in vitro and in vivo bioequivalence studies, biopharmaceuticals, pharmacogenomics, drug-drug and food-drug interactions, and in silico and in vitro prediction of ADME properties. In comparison with other similar textbooks, around half of the volume would be focused on the relationship between expanding scientific fields and ADME processes. Each of these burgeoning fields has a separate chapter in the second part of the volume, and was written with leading experts on the correspondent topic, including scientists and academics from USA and UK (Duquesne University School of Pharmacy, Indiana University School of Medicine, University of Utah College of Pharmacy, University of Maryland, University of Bath). Additionally, each of the initial chapters dealing with the generalities of drug absorption, distribution, metabolism and excretion would include relevant, classic examples related to each topic with appropriate illustrations (e.g. importance of active absorption of levodopa, implications in levodopa administration, drug drug interactions and food drug interactions emerging from the active uptake; intoxication with paracetamol as a result of glutathione depletion, CYP induction and its relationship with acute liver failure caused by paracetamol, etc). ADME Processes and Pharmaceutical Sciences is written as a core textbook for ADME processes, pharmacy, pharmacokinetics, drug delivery, biopharmaceutics, drug disposition, drug design and medicinal chemistry courses.